Sceletium
- joanne looker
- Aug 16
- 2 min read
Sceletium, also known as kanna, is a potent natural herb and succulent plant native to South Africa, traditionally used by the San and Khoikhoi people to relieve stress, reduce hunger and thirst, and enhance mood during long hunts or social gatherings.
The plant was often fermented and chewed, smoked, or brewed into tea, and its effects are linked to active alkaloids such as mesembrine, mesembrenone, and mesembrenol, which act on serotonin and other brain pathways.
Sceletium is valued for its ability to enhance mood, reduce anxiety, and promote emotional balance while supporting mental clarity, calming obsessive thoughts, and encouraging authentic expression. It boosts serotonin more effectively than many other natural supplements like L-Tryptophan or 5-HTP, without causing drowsiness, creating a deep sense of peace and well-being.
By aiding the conversion of serotonin into melatonin, it also supports sleep regulation.
As both a serotonin releasing agent and re-uptake inhibitor, and a natural PDE4 inhibitor, it provides broad emotional, mental, and cognitive support.
Its reported benefits include reducing anxiety and stress, improving mood and emotional well-being, enhancing mental focus, attention, and cognitive function, supporting ADHD symptoms, reducing mild depression, promoting relaxation and social connection, supporting better sleep, providing adaptogenic stress support, calming nervous tension and emotional reactivity, reducing social anxiety, enhancing resilience to burnout, supporting memory and clarity, stabilizing emotional balance, and easing mild withdrawal symptoms from substances such as nicotine or alcohol.
Sceletium has some potential relevance for brain health, including conditions like dementia and Alzheimer’s. Its main effects—boosting serotonin, supporting cognitive clarity, reducing stress, and protecting neural pathways—could theoretically help.
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